The brain-fat tissue connection<\/h2>\n\n\n\n
Leptin is a hormone produced by fat tissues that helps the body control its weight. Leptin production increases as the body’s fat tissue increases. Leptin is transported to the brain, where it tells neurons specialized in fat storage the amount of body fat. Leptin in large amounts tells the brain that fat is stored in large quantities. The brain then triggers behaviors to suppress appetite and increase energy consumption, leading to weight loss and a reduction in fat tissue. This leptin-mediated loop between fat tissue and brain can result in a healthy body weight when everything is working well.<\/p>\n\n\n\n
“Leptin is a promising treatment for obesity because it can prevent excessive weight gain through its ability to inhibit appetite while simultaneously increasing energy expenditure,” said Dr. Yong Xu of Baylor, professor of pediatrics \u2013 nutrition and molecular cellular biology. Leptin supplements are often ineffective for most diet-induced obese patients. This is partly because of the development of leptin resistant, which occurs when leptin levels remain high, but they do not suppress food intake or body weight.<\/p>\n\n\n\n
In this study, Xu’s colleagues searched for molecules that could regulate leptin and be used as a potential tool to overcome resistance to leptin. The team found that the protein Grb10 regulates leptin.<\/p>\n\n\n\n
Xu stated, “We discovered that Grb10 promotes the leptin-like activity.” The mode of action of Grb10 is one of the features that distinguishes it from other leptin regulators previously discovered. Grb10 forms a complex when it binds to the leptin-receptor on neuronal cells. This binding increases leptin signals, which helps to decrease food intake while increasing energy expenditure. Other regulators don’t bind to leptin receptors but to molecules downstream.”<\/p>\n\n\n\n
The mice gained weight after removing Grb10 from leptin receptor neurons in their brains. They either ate more food or decreased energy expenditure. Grb10 was increased and had a positive effect on animals. It helped them reduce food intake, increase their energy expenditure, and lose weight. Xu stated that the results showed that enhancing Grb10 could be a way to boost leptin signals and aid in weight loss. “Our findings support future investigations into the development of a Grb10 based treatment for obesity.”<\/p>\n\n\n\n
The team wants to continue investigating the mechanism of Grb10 in the brain. Xu stated that leptin can also regulate moods and other emotional states. We want to find out if Grb10 regulates mood through interaction with the leptin-receptor.<\/p>\n\n\n\n
Mengjie Wan, Jonathan Carter Bean and Camille Hollan Sidell Potts are also contributors. Feng Liu is the co-corresponding author. The authors are associated with the Baylor College of Medicine and Central South University in China, as well as the University of Texas Health Science Center San Antonio.<\/p>\n\n\n\n
The National Nature Science Foundation of China (31871180, 8173022), National Key R&D Program of China (202020YFA0803604), and the American Heart Association supported the investigators in this study.<\/p>\n\n\n\n Many people find it difficult to maintain a healthy weight. According to the Centers for Disease Control and Prevention (CDC), obesity among adults aged 20 and older is 42%. Conditions such as heart disease, strokes, type 2 diabetics, and cancer are all linked to obesity. Researchers at Baylor College of Medicine and the University of Texas […]<\/p>\n","protected":false},"author":1,"featured_media":181,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[7],"tags":[],"class_list":["post-110","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-cancer"],"_links":{"self":[{"href":"https:\/\/kurir-health.com\/index.php?rest_route=\/wp\/v2\/posts\/110","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kurir-health.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kurir-health.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kurir-health.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/kurir-health.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=110"}],"version-history":[{"count":2,"href":"https:\/\/kurir-health.com\/index.php?rest_route=\/wp\/v2\/posts\/110\/revisions"}],"predecessor-version":[{"id":284,"href":"https:\/\/kurir-health.com\/index.php?rest_route=\/wp\/v2\/posts\/110\/revisions\/284"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/kurir-health.com\/index.php?rest_route=\/wp\/v2\/media\/181"}],"wp:attachment":[{"href":"https:\/\/kurir-health.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=110"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kurir-health.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=110"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/kurir-health.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=110"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}![\"\"](\"https:\/\/kurir-health.com\/wp-content\/uploads\/2023\/05\/image-30.png\")
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