{"id":78,"date":"2022-07-30T07:01:30","date_gmt":"2022-07-30T07:01:30","guid":{"rendered":"https:\/\/kurir-health.com\/?p=78"},"modified":"2023-05-25T11:47:01","modified_gmt":"2023-05-25T11:47:01","slug":"real-world-potential-seen-in-promising-candidate-for-whole-sporozoite-malaria-vaccine","status":"publish","type":"post","link":"https:\/\/kurir-health.com\/?p=78","title":{"rendered":"Real-World Potential Seen in Promising Candidate for Whole-Sporozoite Malaria Vaccine"},"content":{"rendered":"\n<p>A report in&nbsp;<em>Science Translational Medicine<\/em>&nbsp;found that an experimental malaria vaccine containing whole inactivated&nbsp;<em>Plasmodium Falciparum<\/em>sporozoites decreased the risk of infection in adults living in a malaria endemic area.<\/p>\n\n\n\n<p>In a 5-dose regimen with a lower concentration, the vaccine had previously shown greater than 90 percent vaccine efficacy in controlled infections and 52 percent vaccine efficacy in natural infections.&nbsp;In a Burkina Faso region with high transmission, the current study tested an ten-fold higher concentration of vaccine against natural infection.&nbsp;The regimen used 3 doses rather than 5, as it was considered to be more realistic in real-world situations.<\/p>\n\n\n\n<p>The authors reported that at the prespecified endpoint, 24 weeks after the third dose of the vaccine, 36% of the 39 participants who had been vaccinated tested positive for malaria, compared to 58% of the 40 participants who were given a placebo. This translates into a statistically significant efficacy of the vaccine of 38%.<\/p>\n\n\n\n<p>The authors note that the standard method for measuring the efficacy of malaria vaccines is to consider the time delay between vaccination and infection. This resulted in a 48% efficacy.&nbsp;This result was not statistically significant.&nbsp;The report states that 76 weeks later, 77% (of the vaccinated group) tested positive for malaria, compared to 85% (of the placebo group). This resulted in an efficacy of 46% using the standard method.<\/p>\n\n\n\n<p>The authors discovered that the antibody response tests 2 weeks after receiving the last dose of vaccine were higher in participants who received vaccinations than those in placebo groups.&nbsp;After 24 weeks, the antibody levels of vaccinated individuals who had not been infected by malaria were higher than those infected.<\/p>\n\n\n\n<p>The authors concluded that &#8220;this 3-dose regimen is easy to administer and well tolerated. It does not pose any serious safety concerns which would prevent further development.&#8221;<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"768\" height=\"441\" src=\"https:\/\/kurir-health.com\/wp-content\/uploads\/2023\/05\/image-25.png\" alt=\"\" class=\"wp-image-167\" srcset=\"https:\/\/kurir-health.com\/wp-content\/uploads\/2023\/05\/image-25.png 768w, https:\/\/kurir-health.com\/wp-content\/uploads\/2023\/05\/image-25-300x172.png 300w\" sizes=\"auto, (max-width: 768px) 100vw, 768px\" \/><\/figure>\n","protected":false},"excerpt":{"rendered":"<p>A report in&nbsp;Science Translational Medicine&nbsp;found that an experimental malaria vaccine containing whole inactivated&nbsp;Plasmodium Falciparumsporozoites decreased the risk of infection in adults living in a malaria endemic area. In a 5-dose regimen with a lower concentration, the vaccine had previously shown greater than 90 percent vaccine efficacy in controlled infections and 52 percent vaccine efficacy in [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":167,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[6],"tags":[],"class_list":["post-78","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-infectious-diseases"],"_links":{"self":[{"href":"https:\/\/kurir-health.com\/index.php?rest_route=\/wp\/v2\/posts\/78","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kurir-health.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kurir-health.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kurir-health.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/kurir-health.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=78"}],"version-history":[{"count":2,"href":"https:\/\/kurir-health.com\/index.php?rest_route=\/wp\/v2\/posts\/78\/revisions"}],"predecessor-version":[{"id":279,"href":"https:\/\/kurir-health.com\/index.php?rest_route=\/wp\/v2\/posts\/78\/revisions\/279"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/kurir-health.com\/index.php?rest_route=\/wp\/v2\/media\/167"}],"wp:attachment":[{"href":"https:\/\/kurir-health.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=78"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kurir-health.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=78"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/kurir-health.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=78"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}